Lithium isotope enrichment has been identified as a key area of interest for the UK’s fusion community. Without UK-based expertise and domestic supply chain, the full potential of commercial nuclear fusion will not be realised. Additionally other sectors have identified isotopically enriched Li supply chains to be on their critical paths, meaning there is considerable demand for Li isotopes. Traditional enrichment technologies rely on high energy, often hazardous methods (e.g. centrifuge or the use of mercury to extract Li). The potential for isotopic enrichment using low-energy techniques taking advantage of biological processes has not been fully grasped, and this project is demonstrating a commercially scalable method to reliably enrich Li through such means. This process will provide the basis for a low energy, biologically based route for lithium enrichment for nuclear fusion applications. This offers the prospect for a method that is cleaner and cheaper to operate than current Li enrichment methods, both avoiding problematic elements such as mercury and the high energy input required by centrifuges.